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Anti-HIP55 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & M |
| Applications: | WB & ICC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Drebrin-like protein |
Synonyms: | ABP1, Cervical SH3P7, CMAP, DBNL, Drebrin F, drebrin like, Drebrin like protein, HIP 55, SH3P7 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse HIP55 |
Uniprot ID: | Q62418 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 49 kDa / 55 kDa |
Subcellular location: | Cytoplasm, Cell junction, Cell membrane |
Product Usage Information
WB | Human, Mouse, Rat | 1: 1500-1: 2000 | brain |
ICC/IF | Mouse | 1: 100-1: 400 | NIH-3T3 |
Background
Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.
Images
| Western blot analysis of DBNL (GB114891) at dilution of 1: 1500 |
| Immunocytochemistry analysis of 4% paraformaldehyde-fixed NIH-3T3 cells using DBNL (GB114891) at dilution of 1: 200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
