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Anti-HLA-DP Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | HLA-DP rabbit polyclonal |
Gene Name: | HLA class II histocompatibility antigen, DP alpha 1 chain |
Synonyms: | DP(W3), DP(W4), HLA DP1A, HLA DPA1, HLA SB alpha chain, HLADP, HLADPA1, HLA-DPA1, HLASB, MHC class II DP3 alpha, MHC class II DPA1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human HLA-DP |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Cytoplasm |
Uniprot ID: | P20036 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human | 1: 1200-1: 2400 | tonsil |
Background
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
Images
 | Immunohistochemistry analysis of paraffin-embedded human tonsil using HLA-DP (GB113093) at dilution of 1: 2400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
