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Anti-HMBOX1 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Homeobox-containing protein 1 |
Synonyms: | HMBOX1, HNF1LA, homeobox containing 1, Homeobox containing protein 1, PBHNF |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse HMBOX1 |
Uniprot ID: | Q8BJA3 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 47 kDa / 47 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 1000-1: 2000 | brain |
Background
Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (By similarity). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (By similarity). Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres . Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (By similarity). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (By similarity). Might also be involved in the DNA damage response at telomeres (By similarity).
Images
| Western blot analysis of HMBOX1 (GB115092) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
