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Anti-Insulin degrading enzyme / IDE Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | IDE rabbit polyclonal antibody |
Gene Name: | Insulin-degrading enzyme |
Synonyms: | Insulin protease, Insulinase, Insulysin, Ide, FLJ35968, Abeta-degrading protease |
Immunogen: | Recombinant protein corresponding to Mouse IDE |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 118 kDa |
Observed MW. | 120 kDa |
Uniprot ID: | P14735, Q9JHR7, P35559 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | brain, skeletal muscle, colon |
Background
IDE(Insulin-degrading enzyme) belongs to the peptidase M16 family. It is also known as insulysin and is a neutral metallopeptidase that Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.The reduction of IDE expression may be a risk factor for AD, and that IDE may interact with APOE status to affect beta-amyloid metabolism.
Images
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Western blot analysis of IDE (GB111387) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
