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Anti-IGFBP6 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | IGFBP6 rabbit polyclonal antibody |
Gene Name: | Insulin-like growth factor-binding protein 6 |
Synonyms: | IBP-6, IBP6, IGF binding protein 6, IGFBP-6, IGFBP6 |
Immunogen: | Recombinant protein corresponding to Mouse IGFBP6 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 25 kDa |
Observed MW. | 35 kDa |
Uniprot ID: | P47880 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 3000-1: 6000 | liver, kidney, brain |
Background
Insulin-like growth factor (IGF) binding protein (IGFBP6), a 240 amino acid protein, contains an IGFBP N-terminal domain and a thyroglobulin type-1 domain. It modulates the activity of IGF and shows independent effects of IGF, such as growth inhibition and apoptosis. It can decrease the proliferation and survival of cancer cells such as lung cancer cells and naso-pharyngeal cancer cells. IGFBP-6 is distinctive for its 50-fold higher binding affinity for IGF-II over IGF-I and this specificity makes it an attractive potential therapeutic candidate for IGF-II-dependent pediatric malignancies such as rhabdomyosarcoma (RMS). In addition, it was found that IGFBP6 can promote the migration of RMS cells in an IGF-independent manner, and MAPK pathways were involved in this process.
Images
 | Western blot analysis of IGFBP6 (GB114043) at dilution of 1: 5000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
