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Anti-IKK alpha Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | IKK alpha rabbit polyclonal antibody |
Gene Name: | Inhibitor of nuclear factor kappa-B kinase subunit alpha |
Synonyms: | CHUK, IKBKA, IKK-alpha, IKK1, IKKA,NFKBIKA, TCF16, conserved helix-loop-helix ubiquitous kinase |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse IKKα |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Uniprot ID: | O15111, Q60680 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1:200-1:1000 | brain, breast cancer, colon cancer, kidney, lung cancer, testis |
Background
IKK-α is a member of the serine/threonine protein kinase family and forms a complex in the cell with IKK-β and NEMO. NF-κB transcription factors are normally held in an inactive state by the inhibitory proteins IκBs. IKK-α and IKK-β phosphorylate the IκB proteins, marking them for degradation via ubiquitination and allowing NF-κB transcription factors to go into the nucleus.
Once activated, NF-κB transcription factors regulate genes that are implicated in many important cellular processes, including immune response, inflammation, cell death, and cell proliferation.
Images
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Immunohistochemistry of paraffin embedded human breast cancer using IKKα (GB11292-2) at dilution of 1:600 (400x lens) |
| Immunohistochemistry of paraffin embedded human colon cancer using IKKα (GB11292-2) at dilution of 1:600 (400x lens) |
| Immunohistochemistry of paraffin embedded human lung cancer using IKKα (GB11292-2) at dilution of 1:600 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse testis using IKKα (GB11292-2) at dilution of 1:600 (400x lens) |
| Immunohistochemistry of paraffin embedded rat testis using IKKα (GB11292-2) at dilution of 1:600 (400x lens) |
| Immunofluorescence of paraffin embedded mouse kidney using IKKα (GB11292-2) at dilution of 1:600 (400x lens) |
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Immunofluorescence of paraffin embedded rat brain using IKKα (GB11292-2) at dilution of 1:600 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
