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Anti-IKK alpha Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | IKK alpha rabbit polyclonal antibody |
Gene Name: | Inhibitor of nuclear factor kappa-B kinase subunit alpha |
Synonyms: | Chuk, CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16, Conserved helix-loop-helix ubiquitous kinase, Component of inhibitor of nuclear factor kappa B kinase complex |
Immunogen: | Recombinant protein corresponding to Mouse IKKα |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 85 kDa |
Observed MW. | 85 kDa |
Uniprot ID: | O15111, Q60680 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | thymus, testis |
Background
Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.
Images
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Western blot analysis of ikkα (GB11923) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
