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| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | IL-3 rabbit polyclonal antibody |
Gene Name: | Interleukin-3 |
Synonyms: | IL-3, Hematopoietic growth factor, Mast cell growth factor, MCGF, Multipotential colony-stimulating factor, P-cell-stimulating factor, Csfmu |
Immunogen: | Recombinant protein corresponding to Mouse IL-3 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted |
Uniprot ID: | P01586, P04823 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human, Mouse, Rat | 1:900-1:1800 | lung, pneumonia, spleen, splenitis, tonsil |
Background
The pleiotropic IL3 (Interleukin 3) is a 15kDa cytokine that is primarily secreted by activated T lymphocytes and stimulates the proliferation and differentiation of hematopoietic cells. IL3 acts in hematopoiesis by controlling the production, differentiation and function of two related white cell populations of the blood, the granulocytes and the monocytes/macrophages. It induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes and is expressed by activated T cells, mast cells, and natural killer cells. IL3 not only supports growth of both pluripotent stem cells and the more differentiated committed progenitors, but it also stimulates the functional activity of some fully differentiated cells. IL3 has also been shown to protect mast cells from undergoing apoptosis.
Images
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Immunohistochemistry of paraffin embedded human tonsil using IL-3 (GB111178) at dilution of 1:900 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse lung using IL-3 (GB111178) at dilution of 1:900 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse spleen using IL-3 (GB111178) at dilution of 1:900 (400x lens) |
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Immunohistochemistry of paraffin embedded rat pneumonia using IL-3 (GB111178) at dilution of 1:900 (400x lens) |
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Immunohistochemistry of paraffin embedded rat splenitis using IL-3 (GB111178) at dilution of 1:900 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
