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Anti-Inhibin alpha Rabbit pAb (100 μl)
| Reactivity: | R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Inhibin alpha rabbit polyclonal antibody |
Gene Name: | Inhibin alpha chain |
Synonyms: | Inha, A inhibin subunit precursor, IHA, INHA, Inhibin alpha chain precursor |
Immunogen: | Recombinant protein corresponding to Human Inhibin alpha |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted |
Uniprot ID: | P17490 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Rat | 1: 900-1: 1800 | brain, lung, spleen |
Background
The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.
Images
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Immunohistochemistry of paraffin embedded rat brain using Inhibin-Alpha (GB111221) at dilution of 1:900 (400x lens) |
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Immunohistochemistry of paraffin embedded rat lung using Inhibin-Alpha (GB111221) at dilution of 1:900 (400x lens) |
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Immunohistochemistry of paraffin embedded rat spleen using Inhibin-Alpha (GB111221) at dilution of 1:900 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
