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Anti-Insulin Receptor alpha Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Insulin Receptor alpha rabbit polyclonal |
Gene Name: | Insulin receptor |
Synonyms: | CD220, HHF5, INSR, IR, Insulin receptor subunit alpha |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Insulin Receptor alpha |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Endosome, Lysosome |
Uniprot ID: |
Product Usage Information
IHC/IF | Human, Mouse, Rat | 1: 3000-1: 6000 | endometrial cancer, esophagus cancer, uterus, small intestine |
Background
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.
Images
| Immunohistochemistry analysis of paraffin-embedded human endometrial cancer using INSR (GB113494) at dilution of 1: 6000 |
| Immunohistochemistry analysis of paraffin-embedded humanes ophagus cancer using INSR (GB113494) at dilution of 1: 6000 |
| Immunohistochemistry analysis of paraffin-embedded mouse uterus using INSR (GB113494) at dilution of 1: 6000 |
| Immunohistochemistry analysis of paraffin-embedded rat small intestine using INSR (GB113494) at dilution of 1: 6000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
