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| Reactivity: | R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | JMJD6 rabbit polyclonal |
Gene Name: | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 |
Synonyms: | JMJD6, PSR, PTDSR, PTDSR1, arginine demethylase and lysine hydroxylase |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse JMJD6 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: | Q9ERI5 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human, Mouse, Rat | 1: 1000-1: 2000 | colon, spleen, kidney, heart, stomach cancer |
IF | Human, Mouse, Rat | 1: 1000-1: 3000 | colon, spleen, kidney, heart, stomach cancer |
Background
Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis.
Images
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Immunohistochemistry analysis of paraffin-embedded human colon cancer using JMJD6 (GB11341) at dilution of 1:2000. |
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Immunohistochemistry analysis of paraffin-embedded human stomach cancer using JMJD6 (GB11341) at dilution of 1:2000. |
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Immunohistochemistry analysis of paraffin-embedded mouse colon using JMJD6 (GB11341) at dilution of 1:2000. |
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Immunohistochemistry analysis of paraffin-embedded mouse kidney using JMJD6 (GB11341) at dilution of 1:2000. |
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Immunohistochemistry analysis of paraffin-embedded rat heart using JMJD6 (GB11341) at dilution of 1:2000. |
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Immunohistochemistry analysis of paraffin-embedded rat spleen using JMJD6 (GB11341) at dilution of 1:2000. |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
