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Anti-JNK1+JNK2+JNK3 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: |
JNK1+JNK2+JNK3 rabbit polyclonal antibody |
| Gene Name: | Mitogen-activated protein kinase 8/9/10 |
| Synonyms: |
JNK1 + JNK2 + JNK3,JNK1/2/3,JNK1+2+3,MAPK8, MAPK9,MAPK10,c Jun N terminal kinase 1,c Jun N terminal kinase 2,c Jun N terminal kinase 3 |
| Immunogen: |
KLH conjugated Synthetic peptide corresponding to human JNK1 |
| Isotype: | IgG |
| Purity: | Affinity purification |
|
Subcellular location: |
Cytoplasm, Nucleus |
| Uniprot ID: | P45983,P45984,P53779 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 200-1: 800 | brain, lung |
Background
JNK1(MAPK8) is a member of the MAP kinase family. JNK1 is activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7.
JNK2 (p54a, SAPK1a), along with JNK1 and JNK3, is thought to play an important role in nuclear signal transduction through its environmental stress activation and subsequent phosphorylation of the nuclear transcription factor p53.
JNK3 is a neuron-specific form of c-Jun N-terminal kinases. Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways of neuronal apoptosis.
Images
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Immunohistochemistry of paraffin embedded mouse brain using JNK123 (GB11018) at dilution of 1:400 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse lung using JNK123 (GB11018) at dilution of 1:400 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat brain using JNK123 (GB11018) at dilution of 1:400 (400x lens) |
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Immunohistochemistry of paraffin embedded rat lung using JNK123 (GB11018) at dilution of 1:400 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
