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Anti-KMT1B / SUV39H2 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SUV39H2 rabbit polyclonal antibody |
Gene Name: | Histone-lysine N-methyltransferase SUV39H2 |
Synonyms: | Histone H3-K9 methyltransferase 2, KMT1B, H3-K9-HMTase 2, Lysine N-methyltransferase 1B, Suppressor of variegation 3-9 homolog 2, Su(var)3-9 homolog 2, SUV39H2 |
Immunogen: | Recombinant protein corresponding to Mouse SUV39H2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: | Q9H5I1 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 500-1: 4000 | breast cancer, hippocampus, testis |
Background
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats.
Images
 | Immunohistochemistry of paraffin embedded human breast cancer using Suv39h2 (GB111054) at dilution of 1:2000 (400x lens) |
 | Immunofluorescence of paraffin embedded human breast cancer using Suv39h2 (GB111054) at dilution of 1:2000 (400x lens) |
 | Immunofluorescence of paraffin embedded mouse hippocampus using Suv39h2 (GB111054) at dilution of 1:2000 (400x lens) |
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Immunofluorescence of paraffin embedded rat testis using Suv39h2 (GB111054) at dilution of 1:2000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
