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Anti-L1CAM Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | L1CAM rabbit polyclonal antibody |
Gene Name: | Neural cell adhesion molecule L1 |
Synonyms: | NCAM-L1, CD171, L1cam, Caml1, L1-NCAM, HSAS, Hyd |
Immunogen: | Recombinant protein corresponding to Human L1CAM |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 141 kDa |
Observed MW. | 220 kDa |
Uniprot ID: | P11627, Q05695 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 500-1: 1000 | brain, cerebellum, cerebral cortex |
Background
L1cam (L1 cell adhesion molecule isoform 1 precursor) is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
Images
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Western blot analysis of CD171 (GB111218) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
