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Anti-LAMTOR1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | LAMTOR1 rabbit polyclonal antibody |
Gene Name: | Ragulator complex protein LAMTOR1 |
Synonyms: | Lamtor1, LAMTOR1, C11orf59, PDRO, Ragulator1, p18, p27RF-Rho, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 |
Immunogen: | Recombinant protein corresponding to Mouse LAMTOR1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 18 kDa |
Observed MW. | 18 kDa |
Uniprot ID: | Q6IAA8, Q9CQ22, Q6P791 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | brain, lung, skin |
Background
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids. Directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.
Images
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Western blot analysis of LAMTOR1 (GB11750) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
