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Anti-LARP7 Rabbit pAb (100 μl)
| Reactivity: | M & M |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | LARP7 rabbit polyclonal antibody |
Gene Name: | La-related protein 7 |
Synonyms: | HDCMA18P, La related protein 7, LARP7, PIP7S |
Immunogen: | Recombinant protein corresponding to Mouse LARP7 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Predicted MW. | 65 kDa |
Observed MW. | 65 kDa |
Uniprot ID: | Q05CL8 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse | 1: 2000-1: 4000 | testis, liver |
IHC/IF | Mouse | 1: 1000-1: 2000 | testis |
Background
LARP7 belongs to the LARP RNA-binding protein family, which includes the lupus LA antigen gene, and modulates the metabolism and function of a variety of RNA species [PMID:20138158]. LARP7 binds to the 7SK RNP complex, and sequesters the positive transcription elongation factor b (P-TEFb) in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. binds to and stabilizes 7sk snRNA[PMID:19416841].
Images
 | Western blot analysis of LARP7 (GB114013) at dilution of 1: 2000 |
 | Immunofluorescence of paraffin embedded mouse testis using LARP7 (GB114013) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
