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| Reactivity: | H,M & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | LIG1 rabbit polyclonal |
Gene Name: | DNA ligase 1 |
Synonyms: | DNA ligase I, Polydeoxyribonucleotide synthase [ATP] 1, Lig1, Lig-1, ATP dependent, Ligase I DNA ATP dependent |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse LIG1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Predicted MW. | 102 kDa |
Observed MW. | 130 kDa |
Uniprot ID: |
Product Usage Information
WB | Human, Mouse | 1: 1000-1: 2000 | testis |
IHC/IF | Human, Mouse, Rat | 1: 3600-1: 7200 | tonsil, spleen, colon |
Background
LIG1, also named as LRIG1, acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.
Images
| Western blot analysis of Lig1 (GB112989) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin-embedded human tonsil using LIG1 (GB112989) at dilution of 1: 7200 |
| Immunohistochemistry analysis of paraffin-embedded mouse spleen using LIG1 (GB112989) at dilution of 1: 7200 |
| Immunohistochemistry analysis of paraffin-embedded rat spleen using LIG1 (GB112989) at dilution of 1: 7200 |
| Immunohistochemistry analysis of paraffin-embedded mouse colon using LIG1 (GB112989) at dilution of 1: 7200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
