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Anti-Lipocalin-2 / NGAL Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | NGAL rabbit polyclonal antibody |
Gene Name: | Neutrophil gelatinase-associated lipocalin |
Synonyms: | NGAL, Lipocalin-2, Oncogene 24p3, Siderocalin, p25 |
Immunogen: | Recombinant protein corresponding to Human NGAL |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted |
Uniprot ID: | P80188 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human | 1: 500-1: 3000 | colon, liver, liver cancer, lung, lung cancer |
Background
Lipocalin 2 is a member of the lipocalin family, It involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis.
Images
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Immunohistochemistry of paraffin embedded human liver using NGAL (GB111134) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded human liver cancer using NGAL (GB111134) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded human lung using NGAL (GB111134) at dilution of 1:1000 (400x lens) |
| Immunohistochemistry of paraffin embedded human lung cancer using NGAL (GB111134) at dilution of 1:1000 (400x lens) |
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Immunofluorescence of paraffin embedded human colon using NGAL (GB111134) at dilution of 1:2000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
