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Anti-MASH1/Achaete-scute homolog 1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | MASH1 rabbit polyclonal antibody |
Gene Name: | Achaete-scute homolog 1 |
Synonyms: | ASCL1, ASH1, HASH1, MASH1, bHLHa46, Achaete-scute family bHLH transcription factor 1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse MASH1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 25 kDa |
Observed MW. | 25 kDa |
Uniprot ID: | P50553, Q02067, P19359 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | brain, cerebral cortex |
Background
Achaete-scute homolog 1 is a protein that is encoded by the ASCL1 gene. This protein is a member of the basic helix-loop-helix (BHLH) family of transcription factors and activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. It is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers. The presence of a CAG repeat in the gene suggests that it may also play a role in tumor formation.
Images
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Western blot analysis of MASH1(ASCL1) (GB11745) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
