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| Reactivity: | H & H |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | MCL1 rabbit polyclonal |
Gene Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog |
Synonyms: | Mcl1, MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT, Myeloid cell leukemia 1, BCL2 family apoptosis regulator, BCL2 family apoptosis regulator |
Immunogen: | Recombinant protein corresponding to Human MCL1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human | 1: 500-1: 1500 | colon |
IF | Human | 1: 250-1: 750 | colon |
Background
Induced myeloid leukemia cell differentiation protein Mcl-1 belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing.
Images
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Immunohistochemistry analysis of paraffin-embedded human colon using MCL1 (GB11696) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
