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| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | DNA helicase MCM8 |
Synonyms: | C20orf154, MCM8, Minichromosome maintenance 8, REC |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse MCM8 |
Uniprot ID: | Q9CWV1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 92 kDa / 92 kDa |
Product Usage Information
WB | Human | 1: 500-1: 800 | HeLa |
Background
Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression.
Images
| Western blot analysis of MCM8 (GB114306) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
