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| Reactivity: | H,M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | MEK2 rabbit polyclonal antibody |
Gene Name: | Dual specificity mitogen-activated protein kinase kinase 2 |
Synonyms: | MAP kinase kinase 2, Prkmk2 ,Mek2, Mkk2, Map2k2, ERK activator kinase 2, MAPK/ERK kinase 2, MAPKK 2, PRKMK 2, PRKMK2 V |
Immunogen: | Recombinant protein corresponding to Mouse MEK2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Predicted MW. | 44 kDa |
Observed MW. | 48 kDa |
Uniprot ID: | P36507, Q63932, P36506 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | lung, brain |
IHC/IF | Mouse, Rat | 1: 500-1: 2000 | brain, lung, spleen |
Background
MAP kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax.
Images
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Western blot analysis of MEK2 (GB111018) at dilution of 1: 500 |
 | Immunohistochemistry of paraffin embedded mouse brain using MEK2 (GB111018) at dilution of 1: 2000 (350x lens) |
 | Immunohistochemistry of paraffin embedded mouse brain using MEK2 (GB111018) at dilution of 1: 2000 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat brain using MEK2 (GB111018) at dilution of 1: 2000 (400x lens) |
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Immunohistochemistry of paraffin embedded rat lung using MEK2 (GB111018) at dilution of 1: 2000 (400x lens) |
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Immunohistochemistry of paraffin embedded rat spleen using MEK2 (GB111018) at dilution of 1: 2000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
