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Anti-MEKK3 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | MEKK3 rabbit polyclonal antibody |
Gene Name: | Mitogen-activated protein kinase kinase kinase 3 |
Synonyms: | MAPK/ERK kinase kinase 3, MEK kinase 3, MEKK 3, Map3k3, Mekk3 |
Immunogen: | Recombinant protein corresponding to Mouse MEKK3 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 71 kDa |
Observed MW. | 78 kDa |
Uniprot ID: | Q99759, Q61084, B5DF98 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 800-1: 1000 | liver, lung |
Background
The mitogen-activated protein/ERK kinase kinase 3 (MEKK3) is a member of a family of MEKK/Ste11 serine/threonine protein kinases. One function of MEKK3 is to serve as an upstream regulatory kinase in the mitogen activated protein kinase cascade, however, it also plays a critical role in other signaling pathways. MEKK3 regulates several important functions including cell survival and proliferation. It is ubiquitously expressed in multiple tissues and has been found in complexes with scaffold proteins and other kinases.Cerebral cavernous malformations (CCMs) complex regulation of MEKK3 is essential during vertebrate heart development. MEKK3 signalling and KLF2/4 may be targeted to develop new CCM therapeutics.
Images
| Western blot analysis of mekk3 (GB111020) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
