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Anti-MYL12B Rabbit pAb (100 μl)
| Reactivity: | H & H |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | MYL12B rabbit polyclonal |
Gene Name: | Myosin regulatory light chain 12B |
Synonyms: | MLC 2, MLC 2A, MLC B, MLC20, MRLC2, MYL12B, MYLC2B, SHUJUN 1, Myosin regulatory light chain 20 kDa, Myosin regulatory light chain MRLC2 |
Immunogen: | Recombinant protein corresponding to Mouse MYL12B |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 20 kDa |
Observed MW. | 20 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 300-1: 1000 | skeletal muscle |
Background
MYL12B is a regulatory subunit of myosin and plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. There are two groups of residues on the MYL12B that are phosphorylated by distinct kinases and have contrasting effects on myosin II biophysical properties.Phosphorylation at Thr18/Ser19 essentially "activates" the myosin molecule to produce force. The second group of phosphorylated residues is at the N-terminus of the MYL12B at Ser1, Ser2 and Thr9 and causes inhibitory effect on myosin activity.
Images
 | Western blot analysis of MYL12B (GB113520) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
