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Anti-Mesothelin Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Mesothelin rabbit polyclonal antibody |
Gene Name: | Mesothelin |
Synonyms: | Pre-pro-megakaryocyte-potentiating factor, Megakaryocyte-potentiating factor, MPF, Msln, Mes, CAK1, SMR, SMRP, MAN |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Mesothelin |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 69 kDa |
Observed MW. | 49 kDa |
Uniprot ID: | Q61468, Q9ERA7 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | thymus, heart, lung, testis |
Background
Mesothelin is a glycosyl-phosphatidylinositol-anchored glycoprotein present on the cell surface of various human solid tumors. It is expressed on pleural and peritoneal mesothelial cells, but not in other non-neoplastic tissues. The mesothelin gene encodes a 69-71kDa precursor protein that is processed to a 40kDa membrane-bound protein termed mesothelin and a 31kDa shed fragment called megakaryocyte-potentiating factor (MPF) that is released from the cell. Mesothelin is a tumor differentiation antigen present at low levels on a restricted set of normal adult tissues (e.g. mesothelium), and is expressed at high levels in mesotheliomas, as well as ovarian, pancreatic, and lung cancers. Mesothelin may be a new target for immunotherapy.
Images
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Western blot analysis of mesothelin（CA125) (GB111016) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
