Your shopping cart is empty!
Anti-Metabotropic Glutamate Receptor 5 Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Metabotropic Glutamate Receptor 5 antibody |
Gene Name: | Metabotropic glutamate receptor 5 |
Synonyms: | Grm5, Metabotropic Glutamate Receptor 5, GRM5, GPRC1E, MGLUR5, PPP1R86, MGlu5 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human Metabotropic Glutamate Receptor 5 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 128 kDa |
Observed MW. | 128 kDa |
Uniprot ID: | Q3UVX5, P31424 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human | 1: 500-1: 1000 | HeLa, SH-SY5Y |
Background
The amino acid L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacological properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7, and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
Images
 |
Western blot analysis of mGLuR5 (GB11746) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
