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Anti-Myogenin Mouse mAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Myogenin |
Synonyms: | BHLHC3, MYF4 |
Immunogen: | Recombinant protein corresponding to Human Myogenin |
Uniprot ID: | P15173 |
Isotype: | IgG2b,k |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 34-37 kDa / 35 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 500-1: 1000 | skeletal muscle |
Background
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy.Essential for the development of functional embryonic skeletal fiber muscle differentiation.However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity.Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation.During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1.Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis.
Images
| WB analysis of Myogenin(GB12988). Sample: Protein treated by RIPA Lysis Buffer (G2002). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
