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Anti-NFkB p100/NFKB2 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | NFKB2 rabbit polyclonal antibody |
Gene Name: | Nuclear factor NF-kappa-B p100 subunit |
Synonyms: | DNA-binding factor KBF2, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, Nuclear factor NF-kappa-B p52 subunit, Nfkb2, Lyt10, H2TF1 |
Immunogen: | Recombinant protein corresponding to Human NFKB2 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 97 kDa |
Observed MW. | 110 kDa |
Uniprot ID: | Q00653, Q9WTK5, Q5U2Z4 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | lung, spleen, stomach |
Background
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. P52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions.
Images
| Western blot analysis of H2TF1 (GB111053) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
