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| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | NKX2-1 |
Protein Name: | Homeobox protein Nkx-2.1 |
Human Swiss Prot No | P43699 |
Immunogen: | Synthesized peptide derived from human Homeobox protein Nkx-2.1 |
Specificity: | This antibody detects endogenous levels of Homeobox protein Nkx-2.1 |
Source: | Mouse |
Concentration: | 1 mg/ml |
Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
Product Usage Information
| Applications | Species | Dilution | |
| IHC、IF | Human | 1:200-1:500 |
Background
The gene NKX2-1 encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription.
Images
Storage
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
