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Anti-NKX2.8 Rabbit pAb (100 μl)
| Reactivity: | R |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | NKX2.8 rabbit polyclonal |
Gene Name: | Homeobox protein Nkx-2.8 |
Synonyms: | Homeobox protein NK-2 homolog H, Homeobox protein Nkx-2.9, Nkx2-8, Nkx-2.9, Nkx2-9, Nkx2h |
Immunogen: | Recombinant protein corresponding to Mouse NKX2.8 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Rat | 1: 3000-1: 6000 | brain, heart |
Background
The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects.
Images
| Immunohistochemistry analysis of paraffin-embedded rat brain using NKX2.8 (GB113363) at dilution of 1: 6000 |
| Immunohistochemistry analysis of paraffin-embedded rat heart using NKX2.8 (GB113363) at dilution of 1: 6000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
