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Anti-NMDAR2B Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Glutamate receptor ionotropic, NMDA 2B |
Synonyms: | GRIN2B, GluN2B, MRD6, NMDAR2B, NR2B, hNR3, EIEE27 |
Immunogen: | KLH conjugated Synthetic phosphopeptide corresponding to Mouse NMDAReceptor 2B |
Uniprot ID: | Q01097 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 166 kDa / 190 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 300-1: 500 | brain |
Background
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity.
Images
| Western blot analysis of NMDAReceptor (GB115472) at dilution of 1: 300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
