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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | NRG1 rabbit polyclonal antibody |
Gene Name: | Pro-neuregulin-1, membrane-bound isoform |
Synonyms: | Pro-NRG1, Neuregulin-1, ARIA, Breast cancer cell differentiation factor p45, Glial growth factor, Heregulin, HRGA, NDF, SMDF, HGL,HRG, Neu differentiation factor, Sensory and motor neuron-derived factor, NRG1, GGF |
Immunogen: | Recombinant protein corresponding to Human NRG1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 70 kDa |
Observed MW. | 55 kDa (mature); 72 kDa (precursor) |
Uniprot ID: | Q02297, P43322 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | lung |
Background
The NRG1 was originally identified as a glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.
Images
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Western blot analysis of NRG1 (GB111258) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
