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| Reactivity: | M,R & M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | NUMB rabbit polyclonal |
Gene Name: | Protein numb homolog |
Synonyms: | Numb, NUMB, C14orf41, S171, c14_5527, Endocytic adaptor protein, NUMB endocytic adaptor protein |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse NUMB |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Membrane |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 500-1: 2000 | brain |
IF | Mouse, Rat | 1: 250-1: 500 | brain |
Background
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
Images
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Immunohistochemistry analysis of paraffin-embedded mouse brain using NUMB (GB11765) at dilution of 1: 500 |
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Immunohistochemistry analysis of paraffin-embedded rat brain using NUMB (GB11765) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
