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Anti-Neurofascin Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Neurofascin rabbit polyclonal antibody |
Gene Name: | Neurofascin |
Synonyms: | Nfasc, KIAA0756 , Neurofascin homolog, NRCAML, Nfasc, NF |
Immunogen: | Recombinant protein corresponding to Mouse Neurofascin |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 138 kDa |
Observed MW. | 186 kDa |
Uniprot ID: | Q810U3, P97685 |
Applications
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 500-1: 1000 | brain, cerebral cortex, hippocampus, cerebellum |
Background
Neurofascin encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin.
Images
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Western blot analysis of Neurofascin (GB111351) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
