Your shopping cart is empty!
Anti-Notch2 Rabbit pAb (100 μl)
| Reactivity: | H & H |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Notch2 rabbit polyclonal antibody |
Gene Name: | Notch receptor 2 |
Synonyms: | AGS2, hN2, Notch 2, Notch homolog 2 (Drosophila), NOTCH2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human Notch2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm, Cell membrane |
Predicted MW. | 269 kDa |
Observed MW. | 110/300 kDa |
Uniprot ID: | Q04721 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human | 1: 300-1: 600 | HeLa, HEK293, T47D, A-431, HepG2 |
IHC/IF | Human | 1: 600-1: 1200 | esophageal cancer, colon cancer, ovarian cancer |
Background
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development.
Images
 | Western blot analysis of Notch2 (GB113977) at dilution of 1: 600 |
 | Immunohistochemistry of paraffin embedded human esophageal cancer using Notch2 (GB113977) at dilution of 1: 1200 (400x lens) |
 | Immunohistochemistry of paraffin embedded human colon cancer using Notch2 (GB113977) at dilution of 1: 1200 (400x lens) |
 | Immunohistochemistry of paraffin embedded human lung squamous cell carcinoma using Notch2 (GB113977) at dilution of 1: 1200 (400x lens) |
 | Immunohistochemistry of paraffin embedded human ovarian cancer using Notch2 (GB113977) at dilution of 1: 1200 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
