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Anti-Nucleophosmin Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Nucleophosmin rabbit polyclonal antibody |
Gene Name: | Nucleophosmin |
Synonyms: | NPM, Nucleolar phosphoprotein B23, Nucleolar protein NO38, Numatrin, Npm1 |
Immunogen: | Recombinant protein corresponding to Mouse Nucleophosmin |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Predicted MW. | 33 kDa |
Observed MW. | 40 kDa |
Uniprot ID: | P06748, Q61937, P13084 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | lymph node, ovary, colon |
IHC/IF | Human, Mouse, Rat | 1: 500-1: 3000 | liver, placenta, prostate, renal cancer, testis, thymus |
Background
NPM1 is a ubiquitously expressed phosphoprotein involved in ribosome assembly/transport, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication, and regulation of p53. NPM1 may prevent protein aggregation via its chaperon activities, protect enzymes during thermal denaturation, and facilitate renaturation of chemically denatured proteins. The NPM1 is believed to act as the interface for oligomerization and oncogenic conversion of these tumor promoting fusion proteins.
Images
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Western blot analysis of Nucleophosmin (GB111375) at dilution of 1: 500 |
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Immunohistochemistry of paraffin embedded human liver using Nucleophosmin (GB111375) at dilution of 1: 1600 (400x lens) |
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Immunohistochemistry of paraffin embedded human renal cancer using Nucleophosmin (GB111375) at dilution of 1: 1600 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse placenta using Nucleophosmin (GB111375) at dilution of 1: 1600 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse testis using Nucleophosmin (GB111375) at dilution of 1: 1600 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse thymus using Nucleophosmin (GB111375) at dilution of 1: 1600 (400x lens) |
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Immunohistochemistry of paraffin embedded rat placenta using Nucleophosmin (GB111375) at dilution of 1: 1600 (400x lens) |
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Immunohistochemistry of paraffin embedded rat testis using Nucleophosmin (GB111375) at dilution of 1: 1600 (400x lens) |
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Immunohistochemistry of paraffin embedded rat thymus using Nucleophosmin (GB111375) at dilution of 1: 1600 (400x lens) |
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Immunofluorescence of paraffin embedded human prostate using Nucleophosmin (GB111375) at dilution of 1: 1600 (400x lens) |
| Immunofluorescence of paraffin embedded mouse placenta using Nucleophosmin (GB111375) at dilution of 1: 1600 (400x lens) |
| Immunofluorescence of paraffin embedded mouse testis using Nucleophosmin (GB111375) at dilution of 1: 1600 (400x lens) |
| Immunofluorescence of paraffin embedded rat testis using Nucleophosmin (GB111375) at dilution of 1: 1600 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
