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| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Cyclin-dependent kinase inhibitor 1 |
Synonyms: | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1, p21, cyclin-dependent kinase inhibitor 1A, cyclin dependent kinase inhibitor 1A |
Immunogen: | Recombinant protein corresponding to Human P21 |
Uniprot ID: | P38936 |
Isotype: | IgG1,κ |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Product Usage Information
IHC/IF | Human, Mouse, Rat | 1: 500-1: 1500 | cervical cancer, testis |
Background
Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (By similarity). Regulates the expression of numerous target genes, including EPO . Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors.
Images
| Immunohistochemistry analysis of paraffin embedded human cervical cancer using p21 (GB12153) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human cervical cancer using p21 (GB12153) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded mouse testis using p21 (GB12153) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
