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| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Paired box protein Pax-5 |
Synonyms: | BSAP, BSAP,PAX5, paired box 5, Paired box protein Pax 5, PAX5 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse PAX5 |
Uniprot ID: | Q02650 |
Isotype: | lgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 42 kDa / 45 kDa |
Product Usage Information
WB | Mouse | 1: 300-1: 400 | A20 |
Background
Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage. Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes. In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage. Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (By similarity).
Images
| WB analysis of PAX5 (GB115495). Sample: Protein treated by RIPA Lysis Buffer (G2002). Blocking buffer: 3% Nonfat dry milk (GC310001) in TBST, RT, 1h. Primary antibody: 1: 300, 4°C overnight. Secondary antibody: HRP Goat Anti-Rabbit lgG (GB23303), 1: 3000, RT, 1h. |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
