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Anti-PDE9A Rabbit pAb (100 μl)
| Reactivity: | R & H |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
Synonyms: | FLJ90181, Pde9a, HSPDE9A2, High affinity cGMP-specific 3'', Phosphodiesterase 9A |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse PDE9A |
Uniprot ID: | O70628 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell projection, Cytoplasm |
Predicted MW. / Observed MW. | 62 kDa / 62 kDa |
Product Usage Information
WB | Rat | 1: 300-1: 800 | kidney |
IHC/IF | Human | 1: 800-1: 2400 | lung cancer, liver cancer, kidney, liver |
Background
Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart. Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory.
Images
| Western blot analysis of PDE9A (GB114884) at dilution of 1:800 |
| Immunohistochemistry of paraffin embedded human lung cancer using PDE9A (GB114884) at dilution of 1: 800 |
| Immunohistochemistry of paraffin embedded human Liver cancer using PDE9A (GB114884) at dilution of 1: 800 |
| Immunohistochemistry of paraffin embedded human kidney using PDE9A (GB114884) at dilution of 1: 800 |
| Immunohistochemistry of paraffin embedded human liver using PDE9A (GB114884) at dilution of 1: 800 |
| Immunohistochemistry of paraffin embedded human kidney using PDE9A (GB114884) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
