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| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | PERK rabbit polyclonal antibody |
Gene Name: | Eukaryotic translation initiation factor 2-alpha kinase 3 |
Synonyms: | EIF2AK3, PEK, PERK, WRS ,eukaryotic |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human PERK |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Endoplasmic reticulum membrane |
Uniprot ID: | Q9NZJ5 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human | 1: 1000-1: 3000 | breast cancer, endometrial cancer, kidney |
Background
Eukaryotic translation initiation factor 2-alpha kinase 3, also known as protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is an enzyme that in humans is encoded by the EIF2AK3 gene.The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis.
Images
 | Immunohistochemistry of paraffin embedded human endometrial cancer using PERK (GB11507) at dilution of 1:1500 (400x lens) |
 | Immunohistochemistry of paraffin embedded human kidney using PERK (GB11507) at dilution of 1:1500 (400x lens) |
 | Immunofluorescence of paraffin embedded human breast cancer using PERK (GB11507) at dilution of 1:1500 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
