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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | PIAS2 rabbit polyclonal antibody |
Gene Name: | E3 SUMO-protein ligase PIAS2 |
Synonyms: | Androgen receptor-interacting protein 3, DIP, Msx-interacting zinc finger protein, ARIP3, DAB2-interacting protein, Protein inhibitor of activated STAT2, RING-type E3 ubiquitin transferase PIAS2, Miz1, Piasx |
Immunogen: | Recombinant protein corresponding to Mouse PIAS2 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 68 kDa |
Observed MW. | 68 kDa |
Uniprot ID: | O75928, Q8C5D8, Q6AZ28 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | kidney, skeletal muscle |
Background
PIAS2 Antibody: The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS2. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS2 binds specifically to STAT4 following IL-12 stimulation and inhibits STAT4-mediated gene activation in human T cells. PIAS2 is a potent transcriptional activator of Bcl-2, but together with Bcl-6 can suppress the expression of Bcl-2.
Images
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Western blot analysis of pias2 (GB11992) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
