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| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | PNP rabbit polyclonal |
Gene Name: | Purine nucleoside phosphorylase |
Synonyms: | Obinepitide, pancreatic polypeptide, Pancreatic prohormone, PH Pancreatic icosapeptide, PI, PNP, PP, PPY |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse PNP |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 32 kDa |
Observed MW. | 32 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human | 1: 300-1: 600 | HeLa, Jurkat, K562, Raji, NCI-H460 |
Background
This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2.
Images
 | Western blot analysis of PNP (GB113688) at dilution of 1: 600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
