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| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | PRAK rabbit polyclonal antibody |
Gene Name: | MAP kinase-activated protein kinase 5 |
Synonyms: | Mapkapk5, PRAK, MAPKAPK5, MAPKAP-K5, MK-5, MK5, PRAK, mitogen-activated protein kinase-activated protein kinase 5 |
Immunogen: | Recombinant protein corresponding to Mouse PRAK |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: | Q8IW41, O54992 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 500-1: 2000 | brain, kidney, liver cancer, lung |
Background
MAP kinase-activated protein kinase 5 is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases, including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately-spliced transcript variants of this gene encoding distinct isoforms have been reported.
Images
 | Immunohistochemistry of paraffin embedded human liver cancer using MAPKAPK-5 (GB11721) at dilution of 1:800 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse lung using MAPKAPK-5 (GB11721) at dilution of 1:800 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat lung using MAPKAPK-5 (GB11721) at dilution of 1:800 (400x lens) |
 | Immunofluorescence of paraffin embedded human lung using MAPKAPK-5 (GB11721) at dilution of 1:1000 (400x lens) |
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Immunofluorescence of paraffin embedded mouse brain using MAPKAPK-5 (GB11721) at dilution of 1:1000 (400x lens) |
| Immunofluorescence of paraffin embedded rat kidney using MAPKAPK-5 (GB11721) at dilution of 1:1000 (400x lens) |
| Immunofluorescence of paraffin embedded rat lung using MAPKAPK-5 (GB11721) at dilution of 1:1000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
