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| Reactivity: | M,R & M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | PSCA rabbit polyclonal |
Gene Name: | Prostate stem cell antigen |
Synonyms: | prostate stem cell antigen preproprotein, PRO 232 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human PSCA |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 1000-1: 3000 | kidney |
IF | Mouse, Rat | 1: 500-1: 1000 | kidney |
Background
Prostate stem cell antigen (PSCA) is a 123 amino acid glycosylated protein that shares homology with the Thy-1/Ly-6 family of glycosyl-phosphatidylinositol (GPI)-anchored cell surface antigens. The PSCA gene maps to chromosome 8q24.3 and transcripts are most prevalent in prostate and placenta. The gene encoding c-myc is also located on chromosome 8q and like PSCA, is overexpressed in a large number of prostate cancers. Transcripts for PSCA are also abundant in urothelial tumors, and levels of PSCA transcripts increase in confluent RT112 bladder carcinomas, suggesting that PSCA is a marker for urothelial and gastric tissue carcinogenesis. Among prostate cancer cell surface antigens, PSCA is expressed in over 80% of prostate carcinomas and correlates well to certain prostate cancer phenotypes such as prostate cancer bone metastates.
Images
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Immunohistochemistry analysis of paraffin-embedded mouse kidney using PSCA (GB11944) at dilution of 1: 1500 |
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Immunohistochemistry analysis of paraffin-embedded rat kidney using PSCA (GB11944) at dilution of 1: 1500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
