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Anti-Peroxiredoxin 6 Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Peroxiredoxin-6 |
Synonyms: | 1 Cys, 1 Cys peroxiredoxin, 1 Cys PRX, 24 kDa protein, aiPLA2, Antioxidant protein 2, AOP2, KIAA0106 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse PRDX6 |
Uniprot ID: | O08709 |
Isotype: | lgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Product Usage Information
IHC/IF | Human | 1: 100-1: 200 | lung cancer, Liver cancer, endometrial cancer |
Background
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce HO and short chain organic, fatty acid, and phospholipid hydroperoxides. Has phospholipase activity. Can either reduce the oxidized sn-2 fatty acyl group of phospholipids or hydrolyze the sn-2 ester bond of phospholipids . These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis. Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine into phosphatidylcholine . Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate.
Images
| Immunohistochemistry analysis of paraffin embedded human endometrial cancer using Peroxiredoxin 6 (GB115586) at dilution of 1: 150 |
| Immunohistochemistry analysis of paraffin embedded human Liver cancer using Peroxiredoxin 6 (GB115586) at dilution of 1: 150 |
| Immunohistochemistry analysis of paraffin embedded human lung cancer using Peroxiredoxin 6 (GB115586) at dilution of 1: 150 |
| Immunohistochemistry analysis of paraffin embedded human ovarian cancer using Peroxiredoxin 6 (GB115586) at dilution of 1: 150 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
