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Anti-Pleckstrin Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Pleckstrin rabbit polyclonal |
Gene Name: | Pleckstrin |
Synonyms: | P47, Platelet 47 kDa protein, PLEK, Platelet P47, Platelet and leukocyte C kinase substrate |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Pleckstrin |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 40 kDa |
Observed MW. | 40 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 300-1: 600 | spleen, lung |
Background
PLEK (pleckstrin; also known as p47) was originally identified as the major PKC substrate in platelets and later is found to be expressed in all cells of the hemopoietic system. Through two pleckstrin homology (PH) domains at its N and C termini, PLEK may interact with various protein and/or lipid ligands and serve as an intracellular adaptor/targeting protein. Predominantly cytosolic in unstimulated cells, PLEK would undergo transient redistribution to phagosomal membrane in response to stimuli. PLEK has been found to be hyperphosphorylated in diabetic mononuclear phagocytes and promote proinflammatory cytokine secretion in diabetes.
Images
| Western blot analysis of PLEK (GB113675) at dilution of 1: 600 |
| Western blot analysis of PLEK (GB113675) at dilution of 1: 600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
