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Anti-Prion protein PrP Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Major prion protein |
Synonyms: | ASCR, CD230, CJD, GSS, Major prion protein, prion, prion protein, PRIP, PRNP, PrP, PrP27 30, PrP33 35C, PrPc |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Prion protein PrP |
Uniprot ID: | P04925 |
Isotype: | lgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 28 kDa / 20-40 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 300-1: 500 | brain |
Background
Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains
Images
| WB analysis of PRNP (GB115536). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
