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Anti-Progesterone receptor Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Progesterone receptor rabbit polyclonal |
Gene Name: | Progesterone receptor |
Synonyms: | PGR, NR3C3, PR, progesterone receptor |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Progesterone receptor |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Predicted MW. | 99 kDa |
Observed MW. | 90/120 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human | 1: 300-1: 800 | T47D, MCF-7, MDA-MB-23 |
IHC | Human, Mouse, Rat | 1: 500-1: 4000 | endometrial cancer, uterus |
Background
Progesterone is necessary to induce the progesterone receptors. When no binding hormone is present the carboxyl terminal inhibits transcription. Binding to a hormone induces a structural change that removes the inhibitory action. Progesterone antagonists prevent the structural reconfiguration.
After progesterone binds to the receptor, restructuring with dimerization follows and the complex enters the nucleus and binds to DNA. There transcription takes place, resulting in formation of messenger RNA that is translated by ribosomes to produce specific proteins.
Images
| Western blot analysis of PR (GB11262) at dilution of 1: 800 |
 | Immunohistochemistry analysis of paraffin-embedded human endometrial cancer using PR (GB11262) at dilution of 1: 4000 |
 | Immunohistochemistry analysis of paraffin-embedded human uterus using PR (GB11262) at dilution of 1: 4000 |
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Immunohistochemistry analysis of paraffin-embedded mouse uterus using PR (GB11262) at dilution of 1: 4000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
