Your shopping cart is empty!
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | RB-1 rabbit polyclonal antibody |
Gene Name: | Retinoblastoma-associated protein |
Synonyms: | pRb, Rb, pp105, Rb1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse RB-1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: | P13405, P33568 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 500-1: 2500 | brain, kidney, lung, Skeletal muscle |
Background
RB1 belongs to the retinoblastoma protein family. It is a key regulator of entry into cell division that acts as a tumor suppressor. RB1 acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation.
Images
|
|
Immunohistochemistry of paraffin embedded mouse brain using RB1 (GB111111) at dilution of 1:700 (400x lens) |
|
|
Immunohistochemistry of paraffin embedded mouse kidney using RB1 (GB111111) at dilution of 1:700 (400x lens) |
|
|
Immunohistochemistry of paraffin embedded mouse Skeletal muscle using RB1 (GB111111) at dilution of 1:1400 (400x lens) |
|
|
Immunohistochemistry of paraffin embedded rat brain using RB1 (GB111111) at dilution of 1:1400 (400x lens) |
|
|
Immunohistochemistry of paraffin embedded rat brain using RB1 (GB111111) at dilution of 1:700 (400x lens) |
|
|
Immunohistochemistry of paraffin embedded rat kidney using RB1 (GB111111) at dilution of 1:1400 (400x lens) |
|
|
Immunohistochemistry of paraffin embedded rat lung using RB1 (GB111111) at dilution of 1:700 (400x lens) |
| Immunofluorescence of paraffin embedded mouse Brain using RB1 (GB111111) at dilution of 1:1400 (400x lens) |
 | Immunofluorescence of paraffin embedded mouse Skeletal muscle using RB1 (GB111111) at dilution of 1:1400 (400x lens) |
 | Immunofluorescence of paraffin embedded rat brain using RB1 (GB111111) at dilution of 1:1400 (400x lens) |
|
|
Immunofluorescence of paraffin embedded rat kidney using RB1 (GB111111) at dilution of 1:1400 (400x lens) |
|
|
Immunofluorescence of paraffin embedded rat lung using RB1 (GB111111) at dilution of 1:1400 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
