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Anti-RIC8A Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | RIC8A rabbit polyclonal antibody |
Gene Name: | Synembryn-A |
Synonyms: | Protein Ric 8A, RIC8, RIC8A, synembryn, Synembryn A |
Immunogen: | Recombinant protein corresponding to Mouse RIC8A |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 60 kDa |
Observed MW. | 60 kDa |
Uniprot ID: | Q3TIR3 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human | 1: 3000-1: 6000 | 293T, A-431 |
Background
RIC8A, also named as synembryn-A, is a Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. It is involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. RIC8A also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
Images
 | Western blot analysis of RIC8A (GB113994) at dilution of 1: 3000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
